Rhode Island Science and Technology Advisory Council (STAC)

Making Innovation Central to Rhode Island's Future Gina M. Raimondo, Governor

Last Updated
Jun 3, 2008

Microcal VP-ITC


Isothermal Titration Calorimetry (ITC) is a particularly suitable and powerful method to study the thermodynamics of protein:protein and protein:ligand interactions. ITC measures the change in heat upon interaction between two molecules. The experimental setup is quite simple: A syringe containing a "ligand" (either a small molecule ligand or an interacting protein) is titrated into a highly temperature controlled cell containing the protein solution.


RI Proteomics Center, James Clifton, PhD at James_Clifton@brown.edu or (401) 863-7095

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